During pregnancy and lactation, our need for folic acid increases, as a great deal of cell division takes place within the framework of the formation of the organs, development of the body and the wasting of the embryo/baby. For this to work without any problems, we need more folic acid.
An adequate folate intake is therefore particularly important in the first trimester (the first three months of pregnancy). Due to its effect on homocsystein metabolism, a sufficient folate intake is recommended throughout the entire pregnancy.
Studies have shown that maternal folic acid and vitamin B12 levels decrease especially at the end of pregnancy and the total homocysteine in the blood increases in the same way. QOllic acid also regulates homocysteine levels, if it is too high, there is a risk of miscarriages and premature births, as well as the risk of pregnancy and birth-associated problems.
For example, studies have shown that pregnant women who supplement folic acid had a nidrigesese risk of genosis such as preclampsia and were less likely to give birth to children with too low birth weight or prematurebirth. Some studies have shown that folic acid supplementation may protect against anxiety depression.
- Kim MW et al.: Preventive effects of folic acid supplementation on adverse maternal and fetal outcomes. PLoS One. 2014; 9(5): e97273.
- Kim MW et al.: Homocysteine, folate and pregnancy outcomes. J Obstet Gynaecol. 2012 Aug;32(6):520-4.
- Bergen NE et al.: Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study. BJOG. 2012 May;119(6):739-51.
- Xu Y et al.: [Association between folic acid supplement in peri-conceptional period and depression in pregnancy: a cohort study]. Zhonghua Liu Xing Bing Xue Za Zhi. 2014 Jun;35(6):641-5.
- Ubeda N et al.: Physiologic changes in homocysteine metabolism in pregnancy: a longitudinal study in Spain. Nutrition. 2011 Sep;27(9):925-30.